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Scientific publication on SARS-CoV-2 virus detection methods by the KARYO team
On December 2019, a new coronavirus disease (COVID-19) emerged in China and spread worldwide, causing acute severe respiratory syndrome. Due to the increased transmission rate of the virus, it became of great importance the early diagnosis of the disease. The coronavirus pandemic led to the development of numerous tests in order to mass screening population for active viral load and for the identification of antibodies for epidemiological purposes. This review summarizes the different diagnostic tests available to the clinicians for the diagnosis and follow up of the SARS COV-2 infections.
MagCore® HF16
MagCore® HF16 is a simple, fast and cost-effective technique to automatically purify nucleic acids from a wide range of sample types for applications like gene expression analysis, clinical molecular diagnosis, human identity testing, forensics, and biomedical research. The MagCore® HF16 System enables the parallel processing of up to 16 samples per run. With the pre-programmed protocols and magnetic bead based reagent cartridges, the system provides consistent and stable nucleic acid purification for every busy laboratory.
LightCycler® 480 Instrument II
The LightCycler® 480 System is a high-performance, medium- to high-throughput PCR platform (96- or 384-well plates) that provides various methods for gene detection, gene expression analysis, genetic variation analysis, and array data validation. The system features the LightCycler® 480 Instrument, a versatile, plate-based real-time PCR device that supports mono- or multicolor applications, as well as multiplex protocols. The benchtop instrument is easily customizable to meet changing user requirements, and can be integrated into everyday use as a robotically controlled, automated high-throughput solution. The LightCycler® 480 Instrument is designed for general laboratory use and is not intended for use in diagnostic procedures.
COBAS® AmpliPrep/COBAS® TaqMan® System
A fully automated system that improves workflow efficiencies from sample preparation to real-time amplification and detection.
The COBAS® AmpliPrep Instrument isolates RNA or DNA targets for real-time PCR using generic capture with silica-coated glass magnetic beads. This instrument works with both the COBAS® TaqMan® Analyzer or smaller COBAS® TaqMan® 48 Analyzer to help improve throughput.
Ikaros
Ikaros is network-ready and comes as a complete stand-alone system, or as a dedicated workstation either for capturing, analysis, review, or for database maintenance. Ikaros is renowned for its ease of use, flexibility and power. The main reason for its outstanding performance is a remarkable collection of intelligent features, which make it the safest and best system of its kind.
The system combines an intuitive graphic user interface with a variety of powerful tools to provide the flexibility required analyzing even the most complex metaphases. Designed to minimize the number of interactions, Ikaros ensures amazingly fast results, and it is recognized as the fastest system of its kind.
Karyo 3
VideoTesT-Karyo system is designed for automatic karyotyping of the human chromosomes with high accuracy and for analysis of the human chromosomes including an ability to create the chromosome ideograms. The system can work with the images of G-, Q-, and R- banded chromosomes.
ISIS fluorescence imaging system
Isis combines ease of use and functionality which meets the requirements of even the most demanding research and routine applications. With the help of automatic exposure time adjustment, and with the support of most common motorized microscopes, it reliably acquires fluorescence images with up to 12 color channels. For image processing, Isis provides a variety of tools to enhance, edit, annotate, archive, measure, and print the images. The optimized user interface guarantees rapid results in research and routine environments. Isis can be either installed as a stand-alone system, or it can be seamlessly integrated with Ikaros karyotyping stations, the Metafer slide scanning workstation, or any networked multi-user workplace.
Metapher
Automation of metaphase finding and imaging is one of the most efficient ways for improving throughput and quality in classical cytogenetics. MetaSystems offers a modern and flexible imaging solution for routine applications which is based on automated metaphase finding, intelligent unattended image acquisition, and sophisticated case and image data management tools.
Metafer, MetaSystems’ slide scanning platform, offers a unique combination of selected scanning hardware and outstanding imaging software, resulting in the most versatile and robust system available for microscope imaging automation.
Metafer software is unique in its architecture. Based on a core of highly specialized scanning algorithms, all automated microscopy jobs are defined by sets of parameters bundled up in useraccessible classifiers.