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myRISK - Myriad

myRISK - Myriad

Myriad myRisk Hereditary Cancer is a scientific advancement revolutionizing hereditary cancer testing. Blending both genetic test status AND personal cancer family history, Myriad myRisk hereditary cancer panel represents the next generation of hereditary cancer risk testing. Myriad myRisk identifies elevated risk for 8 important cancers by analyzing multiple, clinically significant genes. Additionally, Myriad myRisk provides a summary of available medical society guidelines to help you optimize your patients’ medical management. Be confident you know your patients’ cancer risks and appropriate follow-up management with Myriad myRisk Hereditary Cancer.

myRisk Cancers

Panel Testing

Hereditary cancer panel testing optimizes patient care through increased clinical sensitivity (mutation detection). Testing a broader number of genes associated with multiple cancer risks increases clinical sensitivity. For example, many patients have personal and family history that may be explained by more than one syndrome. One patient may meet Lynch syndrome criteria and another may meet HBOC syndrome criteria. However, there are a significant number of patients that meet criteria for both Lynch and HBOC syndromes, among other risks.

Gene Table

Genes selected for Myriad myRisk™ satisfy these criteria:

  • Cancer Focus
    • Hereditable contribution
    • Association with overlapping syndromes
  • Penetrance
    • Cancer risk is at least 2-3 times the general population
  • Clinically Significant
    • Based on increased cancer risk from societal guidelines or determined by multiple studies
    • Change in management inferred based on risk level
Genes Breast Ovarian Colorectal Endometrial Melanoma Pancreatic Gastric Prostate Other
BRCA1          
BRCA2        
MLH1      
MSH2      
MSH6      
PMS2      
EPCAM      
APC          

MUTYH Biallelic

             
MUTYH Monoallelic                
CDKN2A (p16INK4a)              
CDKN2A (p14ARF)              
CDK4              
TP53
PTEN        
STK11    
CDH1            
BMPR1A          
SMAD4          
PALB2              
CHEK2            
ATM              
NBN              
BARD1                
BRIP              
RAD51C              
RAD51D                

 

Category
Department
Medical specialty
Required sample
Peripheral Blood (EDTA)
Turn around time
2-3 weeks
Technology
NGS