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Familial Breast / Ovarian Cancer Gene Panel (19 genes)

Familial Breast / Ovarian Cancer Gene Panel (19 genes)

In about 15-20% of all breast cancer cases, patients present family history but are free of BRCA1 and BRCA2 genetic alterations. In this case, their cancer is termed familial. Recent research has revealed a number mutations in other genes, some rarely mutated but with high-penetrance and other more commonly mutated with individual low-penetrance but cumulative action, that increase the life time risk for developing breast cancer.

We test for genetic alterations in 19 genes, including BRCA1 and BRCA2, known to be involved in Familial Breast Cancer. The gene list is: AR, ATM, BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2, DIRAS3, HER2, NBN, PALB2, PTEN, RAD50, RAD51, STK11, TP53, CASP8 and TGFB1. Rare genetic syndromes with breast cancer manifestation such as Cowden, Peutz-Jeghers, Li-Fraumeni 1, NF1, Nijmegen, Hereditary diffuse gastric cancer / familial lobular breast cancer, are covered by this test.

Category
Department
Medical specialty
Required sample
Peripheral Blood (EDTA)
Quantity
Turn around time
Genes
Technology
Next Generation Sequencing